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- Piperlongumine, a Piper longum-derived amide alkaloid, protects mice from ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis via suppression of p38 and JNK signaling. Na Luo, Lei Zhang, Chunmei Xiu, Xi Luo, Siyuan Hu, Kaizhong Ji, Qingbai Liu, Jianquan Chen
, Food Funct.
, 2024
, 15
, 2154
- Horner–Wadsworth–Emmons approach to piperlongumine analogues with potent anti-cancer activity. Li-Chen Han, Paul A. Stanley, Paul J. Wood, Pallavi Sharma, Anchala I. Kuruppu, Tracey D. Bradshaw, John E. Moses
, Org. Biomol. Chem.
, 2016
, 14
, 7585
- Polydiacetylene/lipid-coated red-emissive silica nanorods for the sustained release and ameliorated anticancer efficacy of a Ru(arene) complex bearing piperlongumine natural product. Wickneswaran Ishaniya, Chezhiyan Sumithaa, Muthuraman Subramani, Aswathy Karanath-Anilkumar, Ganesh Munuswamy-Ramanujam, Arumugam Madan Kumar, Saravanakumar Rajendran, Mani Ganeshpandian
, Dalton Trans.
, 2024
, 53
, 1616
- The potential role of the 5,6-dihydropyridin-2(1H)-one unit of piperlongumine on the anticancer activity. Wen-Wen Mu, Peng-Xiao Li, Yue Liu, Jie Yang, Guo-Yun Liu
, RSC Adv.
, 2020
, 10
, 42128
- Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF. Rui Xu, Jie Yang, Yun Qian, Huizi Deng, Zhihua Wang, Siyu Ma, Yawen Wei, Ning Yang, Qi Shen
, Nanoscale Horiz.
, 2021
, 6
, 348
- Activity-based protein profiling reveals GSTO1 as the covalent target of piperlongumine and a promising target for combination therapy for cancer. Li Li, Yue Zhao, Ran Cao, Lin Li, Gaihong Cai, Jiaojiao Li, Xiangbing Qi, She Chen, Zhiyuan Zhang
, Chem. Commun.
, 2019
, 55
, 4407
- Identification of an inhibitor of the ubiquitin–proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function. Caroline Haglund, Chitralekha Mohanty, Mårten Fryknäs, Padraig D'Arcy, Rolf Larsson, Stig Linder, Linda Rickardson
, Med. Chem. Commun.
, 2014
, 5
, 376
- Biodegradable nanoassemblies of piperlongumine display enhanced anti-angiogenesis and anti-tumor activities. Yuanyuan Liu, Ying Chang, Chao Yang, Zitai Sang, Tao Yang, Wei Ang, Weiwei Ye, Yuquan Wei, Changyang Gong, Youfu Luo
, Nanoscale
, 2014
, 6
, 4325
- Preparation of piperlongumine-loaded chitosan nanoparticles for safe and efficient cancer therapy. Jayachandran Venkatesan, Moch Syaiful Alam, Eun Ji Hong, Se-Kwon Kim, Min Suk Shim
, RSC Adv.
, 2016
, 6
, 79307
- Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action. Jessica M. Hearn, George M. Hughes, Isolda Romero-Canelón, Alison F. Munro, Belén Rubio-Ruiz, Zhe Liu, Neil O. Carragher, Peter J. Sadler
, Metallomics
, 2018
, 10
, 93