As part of the ChemBioNet, the RBI now hosts and distributes two libraries: the Spectrum Collection and the chemically diverse ChemBioNet library. Libraries are provided and diluted into the desired measuring solutions preferrably in 384-well format at final concentrations of 10-40 µM. Plate reader or fluorescence imaging plate reader capacities of the RBI can be shared for collaborative screening projects. Most compounds that are present in the libraries can be commercially repurchased for further characterisation. Further support includes hit clustering, cherry picking and the design of focussed libraries that test the structure-activity relationship and are expected to help optimising the binding affinity and target selectivity. Ideally, screening activities will result in the establishment of a cell biological tool that can be used for basic science and to intellectual property that may become a starting point for translational activities.
Typical procedures that characterize an academic drug development initiative are visualized in a schematic drawing. Interested scientists are asked to contact Prof. Michael Schaefer.