ChemSpider 2D Image | Muscimol | C4H6N2O2


  • Molecular FormulaC4H6N2O2
  • Average mass114.103 Da
  • Monoisotopic mass114.042931 Da
  • ChemSpider ID4116

More details:

Featured data source

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Muscimol [Wiki]
2763-96-4 [RN]
3(2H)-Isoxazolone, 5-(aminomethyl)- [ACD/Index Name]
5-(Aminomethyl)-1,2-oxazol-3(2H)-on [German] [ACD/IUPAC Name]
5-(Aminomethyl)-1,2-oxazol-3(2H)-one [ACD/IUPAC Name]
5-(Aminométhyl)-1,2-oxazol-3(2H)-one [French] [ACD/IUPAC Name]

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

70015_FLUKA [DBID]
C08311 [DBID]
HSDB 6036 [DBID]
Lopac-G-019 [DBID]
NCGC00015459-01 [DBID]
NCGC00024526-01 [DBID]
NSC 333569 [DBID]
NSC304080 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Toxicity:

      Organic Compound; Amine; Mycotoxin; Fungal Toxin; Natural Compound Toxin, Toxin-Target Database T3D2456
    • Chemical Class:

      A member of the class of isoxazoles that is 1,2-oxazol-3(2<element>H</element>)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus <ital>Amanita</i tal>. ChEBI CHEBI:7035
      A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita. ChEBI
    • Bio Activity:

      <p>Potent, selective and competitive GABA<sub>A</sub> receptor agonist and a potent partial GABA<sub>A</sub>-&rho; (GABAC) receptor agonist.</p> <p><br />Muscimol is a <a href=/gaba.html title=GABA | GABAA agonist | Hello Bio target=_self>GABA</a> analog with comparable potency to GABA and is thought to act at the orthosteric site at GABA<sub>A</sub> receptors in varying active conformations.</p> <p><br />Also acts as a weak inhibitor of GABA uptake but is not a substrate for GABA transaminase.</p> <p><br />Application of muscimol evokes GABA<sub>A</sub>R currents and its actions are antagonized by the GABA<sub>A</sub>R antagonist <a href=/bicuculline.html title=Bicuculline | GABAA antagonist | Hello Bio target=_self>bicuculline</a> (bicuculline <a href=/bicuculline-methochloride.html title=Bicuculline methochloride | GABAA antagonist | Hello Bio target=_self>methochloride</a>, <a href=/bicuculline-methiodide.html title=Bicuculline methiodide | GABAA antagonist | Hello Bio target=_self>methiodide</a> and <a href=/bicuculline-methobromide.html title=Bicuculline methobromide | GABAA antagonist | Hello Bio target=_self>methobromide</a> also available).</p> <p>Muscimol enhances inhibitory neurotransmission and suppresses spontaneous activity. It is commonly used in reversible brain inactivation studies.</p> <p><br />Active in vivo and blood brain barrier permeable.</p> <p>Shows psychoactive, memory impairing effects and anticonvulsant actions at high doses.</p> Hello Bio HB0887
      Biochemicals & small molecules/Agonists & activators Hello Bio HB0887
      GABAA and A-rho Receptors Tocris Bioscience 289
      Ion Channels Tocris Bioscience 289
      Ion channels/Ligand-gated ion channel/GABA<sub>A</sub> Hello Bio HB0887
      Ligand-gated Ion Channels Tocris Bioscience 289
      Potent GABAA agonist Tocris Bioscience 0289, 289
      Potent GABAA receptor agonist and partial GABAA-? receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo. Tocris Bioscience 0289, 289
      Potent GABAA receptor agonist and partial GABAA-rho receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo. Tocris Bioscience 289
      Potent, selective, competitive GABA<sub>A</sub> receptor agonist Hello Bio HB0887
  • Gas Chromatography

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point: 325.0±27.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.7 mmHg at 25°C
Enthalpy of Vaporization: 59.0±3.0 kJ/mol
Flash Point: 150.4±23.7 °C
Index of Refraction: 1.556
Molar Refractivity: 27.0±0.3 cm3
#H bond acceptors: 4
#H bond donors: 3
#Freely Rotating Bonds: 1
#Rule of 5 Violations: 0
ACD/LogP: -0.93
ACD/LogD (pH 5.5): -2.98
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -1.59
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.62
Polar Surface Area: 72 Å2
Polarizability: 10.7±0.5 10-24cm3
Surface Tension: 63.0±3.0 dyne/cm
Molar Volume: 83.9±3.0 cm3

Predicted data is generated using the US Environmental Protection Agency’s EPISuite™

 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  -1.71
    Log Kow (Exper. database match) =  -2.39
       Exper. Ref:  Hansch,C et al. (1995)

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  301.42  (Adapted Stein & Brown method)
    Melting Pt (deg C):  105.68  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  5.04E-005  (Modified Grain method)
    MP  (exp database):  175 deg C
    Subcooled liquid VP: 0.00181 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  5.671e+005
       log Kow used: -2.39 (expkow database)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  1e+006 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Aliphatic Amines

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   1.61E-012  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  1.334E-011 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  -2.39  (exp database)
  Log Kaw used:  -10.182  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  7.792
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   0.8471
   Biowin2 (Non-Linear Model)     :   0.9240
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   2.9715  (weeks       )
   Biowin4 (Primary Survey Model) :   3.7264  (days-weeks  )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :   0.4616
   Biowin6 (MITI Non-Linear Model):   0.3555
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model):  0.9658
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  0.241 Pa (0.00181 mm Hg)
  Log Koa (Koawin est  ): 7.792
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  1.24E-005 
       Octanol/air (Koa) model:  1.52E-005 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  0.000449 
       Mackay model           :  0.000993 
       Octanol/air (Koa) model:  0.00121 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant =  65.6012 E-12 cm3/molecule-sec
      Half-Life =     0.163 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =     1.957 Hrs
   Ozone Reaction:
      OVERALL Ozone Rate Constant =     1.137500 E-17 cm3/molecule-sec
      Half-Life =     1.007 Days (at 7E11 mol/cm3)
      Half-Life =     24.179 Hrs
   Fraction sorbed to airborne particulates (phi): 0.000721 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  52.76
      Log Koc:  1.722 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 0.500 (BCF = 3.162)
       log Kow used: -2.39 (expkow database)

 Volatilization from Water:
    Henry LC:  1.61E-012 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 3.884E+008  hours   (1.619E+007 days)
    Half-Life from Model Lake : 4.238E+009  hours   (1.766E+008 days)

 Removal In Wastewater Treatment:
    Total removal:               1.85  percent
    Total biodegradation:        0.09  percent
    Total sludge adsorption:     1.75  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       3.8e-005        3.37         1000       
   Water     39              360          1000       
   Soil      60.9            720          1000       
   Sediment  0.0713          3.24e+003    0          
     Persistence Time: 579 hr


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